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Morning Briefing

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Tuesday, Jul 18 2023

Full Issue

Eli Lilly's Alzheimer's Drug Slows Disease Progression By 35%; More When Taken Early

Eli Lilly released full clinical trial results that shows promising results for donanemab, which could slow cognitive decline by 60% in patients with mild symptoms. Plus, a first-of-its-kind study provides insight in what parts of the country Alzheimer's is most prevalent.

An experimental Alzheimer's drug from Eli Lilly was shown effective in slowing the disease's progression by about a third 鈥 and more so when it was administered as early as possible, when patients only suffered mild cognitive impairment. Driving the news: The drug giant on Monday released full clinical trial results for its treatment donanemab, which could become the second FDA-approved drug of its kind to receive full approval, and accompanying Medicare coverage. (Gonz谩lez, 7/18)

Lilly's study showed that brain swelling, a known side effect of amyloid-clearing antibodies, occurred in more than 40% of patients with a genetic predisposition to develop Alzheimer's. The company had previously reported that 24% of the overall donanemab treatment group had brain swelling. Brain bleeding occurred in 31% of the donanemab group and about 14% of the placebo group. The deaths of three trial patients were linked to the treatment, researchers reported. (Beasley, 7/17)

But experts caution that donanemab is no cure, and that its benefit amounts to only about a seven-month delay in the loss of memory and thinking. "I do think that will make a difference to people," says Dr. Reisa Sperling, who directs the Center for Alzheimer Research and Treatment at Brigham and Women's Hospital in Boston. "But we have to do better." (Hamilton, 7/17)

Amid hope, caution about Alzheimer's drugs' impact on patients 鈥

鈥淔inally there鈥檚 some hope, right, that we can talk about,鈥 Lilly鈥檚 Dr. John Sims told reporters Monday at the Alzheimer鈥檚 Association International Conference in Amsterdam. 鈥淲e don鈥檛 cure the disease,鈥 he said. 鈥淒iabetes doesn鈥檛 have a cure either 鈥 it doesn鈥檛 mean you can鈥檛 have very meaningful treatments for patients.鈥 (Neergaard, 7/17)

Two Ohio patients who participated in the trials recently spoke to Fox News Digital about how Leqembi has impacted their Alzheimer鈥檚 journeys 鈥 and changed their lives. Joan Murtaugh, 77, lives in Lakewood, Ohio, with her husband, Larry. She first started noticing memory problems nearly seven years ago, just after her 70th birthday. "Timing is everything," her husband, Larry Murtaugh, told Fox News Digital in an interview. "It was Joan who made an appointment at the brain center clinic." (Rudy, 7/18)

Meanwhile, news on where Alzheimer's is prevalent in the U.S. 鈥

Alzheimer鈥檚 disease is most prevalent in the east and southeast, according to new research published Monday that seeks to map out the disease on a state and county level.聽The prevalence of Alzeheimer鈥檚 in those regions is closely tied to demographics and age. (Fortinsky, 7/17)

"It's important for us to know where the prevalences are going to be highest, so that we know how to direct resources and educational opportunities for people," said Dr. Percy Griffin. He is director of scientific engagement for the Alzheimer鈥檚 Association in Chicago, Illinois, and shared his thoughts with Fox News Digital in an interview.聽(Rudy, 7/17)

This is part of the Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
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