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Morning Briefing

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Wednesday, Aug 10 2022

Full Issue

FDA OKs Modified Dosing Method For Monkeypox Vax; US Buys More Tpoxx

The emergency authorization from the Food and Drug Administration will spread limited supplies to reach more people: The method uses a smaller amount of the vaccine administered as an intradermal shot. To combat the virus, the federal government is also buying the IV antiviral drug Tpoxx.

The Food and Drug Administration issued an emergency use authorization on Tuesday for health care providers to administer the monkeypox vaccine in a new way intended to stretch the nation鈥檚 short vaccine supply. There is limited data supporting the method鈥檚 efficacy, indicating how much pressure the Biden administration is under now to stop the spreading virus after its arrival in the spring caught the administration flat-footed. (Mahr and Foley, 8/9)

Florida has nearly doubled its count of people infected by the monkeypox virus in the past week, prompting state health officials to stretch vaccine supplies by only administering the first of two shots. The Florida Department of Health counted 985 people infected by the monkeypox virus as of Tuesday, marking a jump from the 525 infections reported by Surgeon General Joseph A. Ladapo one week ago. The agency also ordered the full 72,000 vaccine doses allocated by the U.S. Department of Health and Human Services, which will be delivered in installments through October. (Sarkissian, 8/9)

Dr. Cassandra Pierre, Boston Medical Center鈥檚 associate hospital epidemiologist and medical director of public health programs, said she agreed with the decision, despite doubts about the data on how long single-dose immunity lasts. 鈥淲e鈥檙e really trying to sprint to prevent this infection from becoming endemic,鈥 she said. State health officials said that a single dose provides substantial, rapid protection from monkeypox infection, and the second dose will provide long-term immunity even if given months later. (Freyer, 8/9)

The U.S. government will buy $26M worth of the Tpoxx antiviral drug 鈥

The U.S. government will buy Siga Technologies Inc's $26-million worth of intravenous formulation of antiviral drug Tpoxx, the company said on Tuesday, as the country fights an outbreak of monkeypox cases. The company plans to deliver by next year the order for the IV treatment, which would be a vital option for patients unable to swallow the oral pill as monkeypox symptoms include rashes and blisters in the mouth. (8/9)

While a national shortage of vaccines has choked efforts to combat the spread of the monkeypox virus, public health officials say an antiviral medication has shown promise to alleviate symptoms for infected people. The problem: They cannot prescribe the medication Tecovirimat, also known as Tpoxx, without completing hours of paperwork because the FDA has classified it as an investigational new drug to treat monkeypox. (Gardiner, 8/9)

More on the spread of monkeypox 鈥

A gradual decline of herd immunity against the closely related smallpox virus gave monkeypox more possibilities to jump from its natural animal hosts, infection-disease experts say. And one day, years ago, it infected someone who was part of a network with close physical contact between members鈥攎aybe a gay man with multiple sexual partners, or a sex worker鈥攁llowing it to spread sustainably among humans for the first time, these experts theorize. (Roland, 8/9)

The explosive trajectory of monkeypox to nearly 90 countries since the current outbreak was detected in the United Kingdom in mid-May has caught many governments off-guard, and created confusion about how monkeypox spreads from person to person. (Molteni, 8/10)

It鈥檚 possible, and even expected, to see infections in children, health experts say. But it won鈥檛 be as common as other viruses. 鈥淲e鈥檙e not expecting that childcare settings and schools will see rampant monkeypox infections run through kids,鈥 said Dr. Ibukan Kalu, assistant professor of pediatrics at the Duke School of Medicine and a medical director of pediatric infection prevention at Duke University Medical Center. 鈥淏ut it is possible for children to get infected.鈥 (Rodriguez, 8/10)

Public health experts are urging universities to prepare for the arrival of monkeypox before students return to campus in the coming weeks. (Muthukumar, 8/9)

On contact tracing 鈥

San Francisco has demanded more vaccines and treatment options for its escalating cases of monkeypox 鈥 but the city has all but abandoned a time-honored method of containing outbreaks: contact tracing. U.S. health officials declared monkeypox a national health emergency last week, as did California and San Francisco city officials, and although it鈥檚 typically non-fatal, no one wants to become infected by the smallpox relative, with its painful lesions that can lead to scarring. (Asimov, 8/8)

Monkeypox in Georgia is infecting an overwhelming number of Black people compared to other races 鈥 a disproportionate effect not anticipated just a few weeks ago, new data from the Georgia Department of Public Health show. Dr. Jonathan Colasanti, an infectious disease specialist, says it鈥檚 important people know the virus is most heavily affecting communities of color 鈥 and that those already infected have access to testing, treatment, and vaccines. (Oliviero, 8/10)

This is part of the Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
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