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Morning Briefing

Summaries of health policy coverage from major news organizations

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Monday, Nov 10 2025

Full Issue

New Cholesterol Breakthroughs Help Reduce LDL Levels, Heart Attack Risk

Merck's new pill, enlicitide, and Amgen's longtime Repatha shot are showing heart attack risk-lowering potential, and researchers have made progress on the gene-editing front.

Merck, the company that introduced statins to the world nearly 40 years ago, has a new, intensely powerful pill that can slash levels of dangerous LDL cholesterol to levels almost never seen in adults. The new pill, enlicitide, blocks a liver protein, PCSK9, that slows the body鈥檚 ability to clear cholesterol. With most PCSK9 blocked, LDL levels plummet and rates of heart attacks and strokes in high risk patients fall by up to 20 percent in just the first year. At least six million adults in the United States are eligible for drugs that block PCSK 9. (Kolata, 11/8)

A cholesterol-lowering injection that鈥檚 been on the market for nearly a decade has now shown its power to cut cardiovascular events in people considered at high risk but who haven鈥檛 yet suffered a heart attack or stroke. (Cooney, 11/8)

With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine. (LaMotte, 11/8)

A statin isn鈥檛 the only answer anymore to lowering cholesterol. The lipid-reducing medicines, among the most widely prescribed drugs in the U.S., have been a mainstay of heart-disease prevention and treatment for decades. But they don鈥檛 work for everyone, and can only reduce harmful 鈥渂ad鈥 cholesterol so much. (McKay, 11/8)

In science news 鈥

He co-discovered DNA鈥檚 structure but later engaged in rank racism and sexism. (Begley, 11/7)

鈥淭he laws of inheritance are quite unknown,鈥 Charles Darwin acknowledged in 1859. The discovery of DNA鈥檚 shape altered how we conceived of life itself. (Zimmer, 11/7)

This is part of the Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
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