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Morning Briefing

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Monday, Nov 28 2022

Full Issue

Next-Gen Gene Editing Tool 'PASTE' Could Replace Broken Genes

A new gene editing technology reported on by the Boston Globe could, it's said, allow fixing of broken genes or "drag-and-drop" editing of large sequences to tackle diseases like cystic fibrosis or cancer. Meanwhile, a study shows eating more flavonols may reduce the risk of memory loss.

Researchers at the Massachusetts Institute of Technology have developed a new gene editing technology that they say can 鈥渄rag-and-drop鈥 large sequences of DNA into the human genome. (Cross, 11/24)

In other science and research 鈥

Eating more flavonols, antioxidants found in many vegetables, fruits, tea and wine, may slow your rate of memory loss, a new study finds. The cognitive score of people in the study who ate the most flavonols declined 0.4 units per decade more slowly than those who ate the fewest flavonols. The results held even after adjusting for other factors that can affect memory, such as age, sex and smoking, according to the study recently published in Neurology, the medical journal of the American Academy of Neurology. (LaMotte, 11/28)

Despite volunteering and working out at the gym several days each week, socializing frequently with friends and family, reading all manner of books and doing daily crossword puzzles, 85-year-old Carol Siegler is restless. 鈥淚鈥檓 bored. I feel like a Corvette being used as a grocery cart,鈥 said Siegler, who lives in the Chicago suburb of Palatine. (LaMotte, 11/27)

Dr. Thomas Perls has for decades studied so-called super agers, people who live deep into their 90s and beyond, essentially unburdened by the typical diseases of old age. He is convinced that the secret to this remarkable longevity is buried in people鈥檚 genes and passed down through generations. (Lazar, 11/27)

Retired running coach Bob Sevene, 79, struggled after his 2019 Parkinson鈥檚 disease diagnosis. The longtime runner suddenly began leaning to the right and was unable to straighten up. He started wearing a back brace and using a walker. A year ago, Sevene began twice-weekly exercise classes designed for Parkinson鈥檚 patients that include high-intensity bouts of noncontact boxing. He also started daily 25-minute speed sessions on a stationary bike and running brief sprints in the hallway outside his apartment. (Cimons, 11/26)

When analyzing the results of the scans, researchers noticed those with chronic or episodic migraines had much enlarged perivascular spaces聽鈥 the fluid-filled spaces that surround blood vessels in the brain and clear the area of waste 鈥 compared to those that don't have migraines. (Mendoza, 11/24)

Susan Downard鈥檚 father died of lung cancer; one of her grandfathers was also diagnosed with the disease. Then, about 12 years ago, doctors found a node on one of Downard鈥檚 lungs. It wasn鈥檛 cancerous, but given her family history, she was concerned. 鈥淵ou have that in your head forever,鈥 she said. (Johnston, 11/27)

This is part of the Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
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