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One in eight US patients hospitalized with a complicated urinary tract infection (cUTI) have a pathogen with resistance to three or more routinely used antibiotic classes, researchers reported yesterday in BMC Infectious Diseases. To assess the prevalence of overlapping resistance to antibiotics commonly used to treat cUTIs and its impact on patient outcomes, the researchers conducted a retrospective study of patients hospitalized with a culture-positive carbapenem-susceptible cUTI using data from approximately 180 US institutions that submitted microbiology data from 2013 through 2018. (2/9)

A study today in mBio offers support to continue breastfeeding infants even when mothers have mild to moderate COVID-19 infections. The study showed breastmilk samples did not contain SARS-CoV-2 (the virus that causes COVID-19) RNA, but the authors suggest risk of transmission via breast skin to baby should be evaluated.The study used multiple breastmilk samples (37) from 14 women following a positive COVID-19 test. None of the 37 samples had detectable SARS-CoV-2 RNA, but two of the infants tested positive for COVID-19. No illnesses were severe. (2/9)

This study provides estimates of the prevalence and risk of breast cancer associated with pathogenic variants in known breast cancer–predisposition genes in the U.S. population. These estimates can inform cancer testing and screening and improve clinical management strategies for women in the general population with inherited pathogenic variants in these genes. (Hu et al, 2/4)

This study aimed to investigate the effect of exercise timing using an individualized approach on PPG in overweight or obese young men. (Zhang et al, 2/9)