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Figure 2 from the PURPOSE-1 trial changed the world. Between gray and red bars representing the study’s background HIV incidence and the arms randomized to receive oral pre-exposure prophylaxis (PrEP) was white space filled only by a previously unimaginable number: zero. Zero infections over one year among the 2,134 cisgender adolescent girls and young women who received the novel long-acting injectable antiretroviral lenacapavir. (Michael Rose, 4/3)

Facility owners may be slacking off right after the inspector departs. (Margaret Morganroth Gullette, 4/3)

A patient came to my office recently and told me she had stopped her statin. She’d been on it for two years. Her coronary artery calcium score was 280 and LDL was 168, up almost 100 points since she had stopped taking her statin. Her father had died from a heart attack at 58. (Vikas Patel, 4/3)

This week's Supreme Court decision ignores how good medicine often comes down to what is said, not just done, by a health care professional. (Peter Jensen, 4/2)

The model combines private ownership with physician leadership, focusing on long-term growth rather than short-term profitability, writes a local health care executive. (Andrew Frankel, 4/3)