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Morning Briefing

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Wednesday, Nov 10 2021

Full Issue

Patient's Brain Swelling, Death After Taking Aduhelm Under Investigation

The newly approved, if controversial, Alzheimer's drug Aduhelm is in the news after a patient who'd taken the medication was hospitalized for brain swelling and then died. The drug's maker Biogen is investigating if there is any link. Meanwhile, a trial finds psilocybin is useful for combatting depression.

Biogen Inc (BIIB.O) said on Tuesday it was investigating the death of a 75-year-old patient who had taken the company's newly approved Alzheimer's drug, Aduhelm, adding that it was not yet known whether it was related to the treatment. The drugmaker's shares were down about 1.2% in afternoon trading. The patient was hospitalized after taking Aduhelm and was diagnosed with swelling in the brain before dying, the company said. (11/9)

Eagerly awaited results of the largest-ever study of psilocybin were announced Tuesday, with Compass Pathways revealing the psychedelic drug was highly efficacious as a therapy for treatment-resistant depression. Still, the company’s stock price dropped 16.4% by the close of trading, perhaps because of safety concerns among investors. The Phase 2b study is the largest randomized, controlled, double-blind trial of psilocybin, the psychedelic compound in magic mushrooms. The company said it found that patients who were given the highest dose, 25 milligrams, had a significant decrease in depressive symptoms compared to those given 1 milligram, which is such a low dose it functions as a placebo. (Goldhill, 11/9)

Bill Mulder was one of the nation's most decorated Navy SEALs. His wife, Sydney Mulder, said he was a great father and dedicated to his SEAL team. "Bill was incredibly proud," she said. "He loved his job." But after a grueling mission to Afghanistan in 2009, Mulder said her husband changed. He was angry, he started drinking excessively and didn't want any help. (Herridge, 11/9)

This is part of the Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
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